These are the most selective colleges in . We've ranked the schools which reject over fifty percent of applicants by rate of acceptance. Leading the list is University of Notre Dame which sent acceptance letters to only 19% of the 19,505 students who applied and rejected 81%. Interestingly, not all schools on our "most selective" lists are overly academically challenging. Schools with less rigorous standardized test and high school GPA requirements may receive a large numbers of qualified applicants and the school does not have the capacity to potentially enroll.