These are the most selective colleges in indiana. We've ranked the schools which reject over fifty percent of applicants by rate of acceptance. Leading the list is University of Notre Dame which sent acceptance letters to only 19% of the 19,564 students who applied and rejected 81%. Interestingly, not all schools on our "most selective" lists are overly academically challenging. Schools with less rigorous standardized test and high school GPA requirements may receive a large numbers of qualified applicants and the school does not have the capacity to potentially enroll.