The Best South Carolina Big Colleges

These are the top ranked large, public and private, four-year colleges in South Carolina as ranked by CollegeSimply. These schools all have total enrollment of 20,000 or more. Leading the list for 2027 is Clemson University. Learn how the Best Large Colleges rankings are calculated on our ranking methodology page.

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South Carolina Large Public Private 4 Year
Clemson University Campus

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  • Public 4 Year
  • Clemson, SC
  • 4.4 | 10 reviews
  • 29,077 total enrollment

Clemson is a large public university known for undergraduate engineering and business. The lakeside campus sits in the Blue Ridge foothills beside Lake Hartwell.

#25 Best Public Universities in America 8/10 Overall Rating
  • SAT Range 1240-1410
  • Predicted Avg GPA 3.75
  • Acceptance Rate 38%
  • Net Price $25,003
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University of South Carolina Columbia Campus

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  • Public 4 Year
  • Columbia, SC
  • 5.0 | 1 reviews
  • 38,532 total enrollment

South Carolina is a large public university known for undergraduate international business and hospitality management. The historic Horseshoe anchors the campus in downtown Columbia.

#2 Best Public Universities in South Carolina 7/10 Overall Rating
  • SAT Range 1180-1360
  • Predicted Avg GPA 3.69
  • Acceptance Rate 60%
  • Net Price $24,488
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