The University of South Carolina Salkehatchie operates as a regional campus of the University of South Carolina system, with two locations in rural Allendale and Walterboro, South Carolina. The main campus in Allendale, established in 1965, sits on 14 acres and features traditional brick academic buildings surrounded by pine forests characteristic of South Carolina's Lowcountry region. USC Salkehatchie primarily serves as a two-year institution where students can complete associate degrees or the first two years of a bachelor's degree before transferring to four-year institutions. The campus offers associate degrees in arts, science, and business, while also providing select bachelor's degree completion programs through partnerships with other USC system institutions. Students have access to on-campus resources including computer labs, a library, and athletic facilities, with the campus fielding competitive teams in baseball, softball, and basketball as part of the National Junior College Athletic Association.
University of South Carolina Salkehatchie is designated as a Predominantly Black Institution (PBI) and receives federal grants supporting the school's efforts to serve low and middle-income Black Americans.